Detail Food Origin Fibrinolytic Enzyme With Multiple Actions (article of HAYATI Journal of Biosciences 24 (2017) 124-130) Bibliografi Author: STEPHANI, LAURENTIA ; Tjandrawinata, Raymond Rubianto ; Afifah, Diana Nur ; Lim, Yanti ; Ismaya, Wangsa Tirta ; Suhartono, Maggy Thenawidjaja Topik: enzyme; fibrinolytic; Oncom; Stenotrophomonas; JABFUNG-YANTI-2018- Bahasa: (EN )     Penerbit: Institut Pertanian Bogor     Tempat Terbit: Bogor    Tahun Terbit: 2017     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 2017_HAYATI_ENZIMFIBRINO.pdf (845.91KB; 2 download) [Informasi yang berkaitan dengan koleksi ini di internet] Abstract Many health related problems such as cardiovascular diseases are associated with the formation of excessive clot in the blood (thrombus). Approaches in cardiovascular disease treatment are preventing the formation or removing the thrombus. The present thrombolytic agents can be classified as plasminogen activators, fibrinolytic enzyme which directly degrades fibrinogen or fibrin andheparin type which act as thrombin inhibitor. Recently, microbial fibrinolytic enzymes of food origin receive more attention that leads to escalating efforts to explore traditional fermented foods as the natural sources. We have successfully isolated microorganism from Indonesian fermented soybean tofu dregs “Oncom” that secretes fibrinolytic enzyme. The microorganism identified asStenotrophomonas sp. is unique because most of the reported fibrinolytic microorganism belongs to Bacillus sp. This isolate was found to produce extracellular fibrinolytic enzyme which could degrade fibrinogen and fibrin directly as determined by fibrinogenzymography and fibrin plate methods. More importantly, the 30-kD purified enzymes was found to demonstrate not only fibrin and fibrinogen degradation capabilities, but also acted as thrombin inhibitor as determined using specific substrates for thrombin. This is the first report of a fibrinolytic enzyme that demonstrates additional synergistic activities. This finding accentuates the importance of further development of the enzyme into a powerful agent to treat the thrombus-related disease effectively. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved