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Antibiofilm activity of actinomycetes: Strategy to overcome biofilm resistance (presented at International Seminar on Tropical Bio-resources for Sustainable Bio-industry, Institut Teknologi Bandung, 30-31 October 2013)
Waturangi, Diana Elizabeth
marine actinomycetes activity
inhibit biofilm formation
School of Life Sciences and Technology, Institut Teknologi Bandung
Papers/Makalah - pada seminar internasional
Antibiofilm Activity of Actinomycetes from doc.pdf
Biofilm is dense aggregate of cell-cell or surface attached microorganisms encased in a hydrated extracellular polymeric substances matrix. Formation of biofilm caused resistance to antimicrobial agents, persistent and chronic bacterial infections. In this study we screened marine actinomycetes activity in inhibit biofilm formation of pathogenic bacteria including Staphylococcus aureus; Streptococcus pneumonia; Enterococcus faecalis; Pseudomonas aeruginosa; Enterotoxigenic Escherichia coli (ETEC), and Vibrio porahaemolyticus. Actinomycetes isolates showed inhibition in biofilm formation as well as positive activity in destruct biofilm formation against Gram negative and Gram positive bacteria in 5% (v/v) and 10% (v/v) concentration. For gram positive bacteria, SW19 isolate had the highest activity to inhibit biofilm formation of S. aureus and S. pneumoniae. Meanwhile, CW17 had the highest activity to inhibit E. faecalis biofilm formation. Isolate CW17 could destruct mature biofilm of S. aureus with the highest activity, isolate TB12, had the highest activity to against S. pneumonia and isolate SW12 could destruct mature biofilm of E. faecalis with highest activity. While for Gram negative bacteria, isolates KP 12, KP 04, and CW 17 had capability to inhibit biofilm formation of P. aeruginosa, ETEC, and V. parahaemolyticus, respectively. Isolate SW 03 had capability to destruct biofilm formation from P. aeruginosa and V. parahaemolyticus, while CW 01 had capability to destruct ETEC biofilm. Further characterization of the bioactive compound of actinomycetes isolates showed that the compound were variety such as polysaccharide, protein, and extracellular DNA. Finding of new metabolite with antibiofilm activity is important as alternative approach to fight infection of pathogens.
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