Anda belum login :: 08 Jun 2023 13:22 WIB
ArtikelDownregulation of Early Visual Cortex Excitability Mediates Oscillopsia Suppression  
Oleh: Ahmad, Hena ; Roberts, R. Edward ; Patel, Mitesh ; Lobo, Rhannon ; Seemungal, Barry ; Arshad, Qadeer ; Bronstein, Adolfo
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Neurology (Official Journal of The American Academy of Neurology) vol. 89 no. 11 (Sep. 2017), page 1179-1185.
Topik: Bilateral Vestibular Failure; BVF
Fulltext: N11 v89 n11 p1179 kelik2017.pdf (518.37KB)
  • Perpustakaan FK
    • Nomor Panggil: N11.K
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
    Lihat Detail Induk
Isi artikelObjective: To identify in an observational study the neurophysiologic mechanisms that mediate adaptation to oscillopsia in patients with bilateral vestibular failure (BVF). Methods: We directly probe the hypothesis that adaptive changes that mediate oscillopsia suppression implicate the early visual-cortex (V1/V2). Accordingly, we investigated V1/V2 excitability using transcranial magnetic stimulation (TMS) in 12 avestibular patients and 12 healthy controls. Specifically, we assessed TMS-induced phosphene thresholds at baseline and cortical excitability changes while performing a visual motion adaptation paradigm during the following conditions: baseline measures (i.e., static), during visual motion (i.e., motion before adaptation), and during visual motion after 5 minutes of unidirectional visual motion adaptation (i.e., motion adapted). Results: Patients had significantly higher baseline phosphene thresholds, reflecting an underlying adaptive mechanism. Individual thresholds were correlated with oscillopsia symptom load. During the visual motion adaptation condition, no differences in excitability at baseline were observed, but during both the motion before adaptation and motion adapted conditions, we observed significantly attenuated cortical excitability in patients. Again, this attenuation in excitability was stronger in less symptomatic patients. Conclusions: Our findings provide neurophysiologic evidence that cortically mediated adaptive mechanisms in V1/V2 play a critical role in suppressing oscillopsia in patients with BVF.
Opini AndaKlik untuk menuliskan opini Anda tentang koleksi ini!

Process time: 0.015625 second(s)