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ArtikelRisk of Epilepsy in Individuals With Posttraumatic Stress Disorder: A Nationwide Longitudinal Study  
Oleh: Chen, Yu-Hsiung ; Wei, Han-Ting ; Ya-Mei Bai ; Ju-Wei Hsu ; Kai-Lin Huang ; Su, Tung-Ping ; Li, Cheng-Ta ; Lin, Wei-Chen ; Wu, Yi-Hui ; Pan, Tai-Long ; Chen, Tzeng-Ji ; Tsai, Shih-Jen ; Chen, Mu-Hong
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Psychosomatic Medicine: Journal of Biobehavioral Medicine vol. 79 no. 06 (Jul. 2017), page 664-669.
Topik: Epilepsy; Temporal association
Fulltext: P01 v79 n6 p664 kelik2017.pdf (1.43MB)
  • Perpustakaan FK
    • Nomor Panggil: P01.K
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
    Lihat Detail Induk
Isi artikelObjective: Several cross-sectional studies have reported a relationship between posttraumatic stress disorder (PTSD) and epilepsy. However, the temporal association between PTSD and epilepsy has rarely been investigated. We hypothesized that the risk of developing epilepsy later in life would be higher in patients with PTSD than in those without PTSD. Methods: Using the Taiwan National Health Insurance Research Database, 6425 individuals with PTSD and 24,980 age-/sex-matched controls were enrolled between 2002 and 2009 in our study and followed up to the end of 2011. Those who developed epilepsy during the follow-up period were identified. Results: Individuals with PTSD had a higher incidence of developing epilepsy (2.65 versus 0.33 per 1000 person-years, p < .001), with an earlier onset of epilepsy (37.53 years [15.80 years] versus 48.11 years [23.97 years], p = .002) than did the controls. Individuals with PTSD had an elevated risk of developing epilepsy (hazard ratio [HR] = 3.72, 95% confidence interval [CI] = 2.27–6.11) during the follow-up after adjustment for demographic data and medical and psychiatric comorbidities. Sensitivity analyses after excluding the observation in the first year (HR = 2.53, 95% CI = 1.44–4.47) and the first 3 years (HR = 2.14, 95% CI = 1.15–4.01) revealed consistent results. Conclusions: These results supported a temporal association between PTSD and the development of epilepsy. Further studies are warranted to investigate the underlying pathophysiological pathways that explain the longitudinal association of PTSD with subsequent epilepsy.
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