Syntheses and Antioxidant Activities of Some Hydroxy Dimethoxy Chalcone Derivatives  

Oleh:

Susanti V. H., Elfi ; Matsjeh, Sabirin ; Mustofa ; Redjeki, Tri ; Wahyuningsih, Tutik Dwi

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Pharmacy vol. 25 no. 01 (Jan. 2014), page 17-24.
Topik: Hydroxy Dimethoxy Chalcone; Claisen-Schmidt Condensation; Grinding; DPPH Method
Fulltext: I03 v25 n1 p17 kelik2017.pdf (456.28KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I03.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Four (4) hydroxy dimethoxy chalcones derivatives were synthesized by Claisen-Schmidt condensation of hydroxyacetophenone with 3,4-dimethoxybenzaldehyde using conventional method and grinding technique. The synthesized compounds were characterized by spectroscopy (IR, 1H-NMR and 13C-NMR). Synthesis of the hydroxy dimethoxy chalcone using grinding method is better than the conventional method. The synthesis using grinding method require a low concentration base, shorter reaction (15min) and higher yield (70-84%). The antioxidant activity of the compounds was determined by DPPH method, showed that 2',5'-dihydroxy-3,4-dimethoxy chalcone have the highest antioxidant activity.

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