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ArtikelA Cis Cold Memory Element and a Trans Epigenome Reader Mediate Polycomb Silencing of FLC by Vernalization in Arabidopsis  
Oleh: Wenya Yuan ; Xiao Luo ; Zicong Li ; Wannian Yang ; Yizhong Wang
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Genetics vol. 48 no. 12 (Dec. 2016), page 1527-1534.
Topik: Epigenetics; Plant Molecular Biology
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  • Perpustakaan FK
    • Nomor Panggil: N12.K
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Isi artikelSome plants acquire competence to flower in spring after experiencing a seasonal temperature drop—winter cold, in a process termed vernalization. In Arabidopsis thaliana, prolonged exposure to cold induces epigenetic silencing of the potent floral repressor locus FLOWERING LOCUS C (FLC) by Polycomb group (PcG) proteins, and this silencing is stably maintained in subsequent growth and development upon return to warm temperatures. Here we show that a cis-regulatory DNA element in the nucleation region for PcG silencing at FLC and two homologous trans-acting epigenome readers, VAL1 and VAL2, control vernalization-mediated FLC silencing. The sequence-specific readers recognize both the cis element (termed the cold memory element) and a repressive mark, trimethylation of histone H3 at lysine 27 (H3K27me3), and directly associate with LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), leading to establishment of the H3K27me3 peak in the nucleation region at FLC during vernalization. Thus, our work describes a mechanism for PcG-mediated silencing by a DNA sequence-specific epigenome reader.
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