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Total Levels, Localization Patterns, and Proportions of Sperm Exhibiting Phospholipase C Zeta are Significantly Correlated with Fertilization Rates after Intracytoplasmic Sperm Injection
Da Silva, Sarah J. Martins
Barratt, Christopher L.
Article from Journal - ilmiah internasional
Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 104 no. 03 (Sep. 2015)
In Vitro Fertilization
Intracytoplasmic Sperm Injection
Total Fertilization Failure
Phospholipase C Zeta
F02 v104 n3 p561 kelik2016.pdf
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Objective: To study the relationship of total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta, with fertilization rates after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Design: Laboratory study; controls vs. patients after IVF (n = 27) or ICSI (n = 17) treatment. Setting: Fertility center. Patient(s): A total of 44 semen samples, subjected to either IVF or ICSI treatment. Oocyte collection, ICSI or IVF, determination of sperm concentration and motility, and immunocytochemical analyses of phospholipase C zeta (PLC?). Intervention(s): None. Main Outcome Measure(s): Percentages of sperm exhibiting PLC?. Result(s): Significant positive correlation between ICSI fertilization rates and total levels, localization patterns, and the proportion (percentage) of sperm exhibiting PLC?. Total levels, localization patterns, and the proportion of sperm exhibiting PLC? are correlated with fertilization rates for ICSI, but not for IVF. Conclusion(s): Evaluating total levels, localization patterns, and proportions of PLC? may represent a useful diagnostic tool for clinical purposes in men for whom IVF is not advised or has previously failed. This clinical study further supports the fundamental role of PLC? in the oocyte activation process.
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