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ArtikelIndian Women of Childbearing Age Do Not Metabolically Conserve Arginine as Do American and Jamaican Women  
Oleh: Kao, Christina C. ; Hsu, Jean W. ; Dwarkanath, Pratibha ; Karnes, Jeffrey M ; Baker, Tameka M.
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 145 no. 05 (May 2015), page 884-892.
Topik: arginine; arginase; American; Jamaican; Indian women
  • Perpustakaan FK
    • Nomor Panggil: J42.K
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Isi artikelBackground: In a previous study in pregnant American women, we reported that arginine flux and nitric oxide synthesis increased in trimester 2. More recently, we reported that Indian women do not increase arginine flux during pregnancy as their American or Jamaican counterparts do. Objective: The purpose of this study was to determine whether Indian women of childbearing age are producing less arginine and/or catabolizing more arginine and therefore have less available for anabolic pathways than do Jamaican and American women. Methods: Thirty healthy women aged 28.3 ± 0.8 y from the United States, India, and Jamaica (n = 10/group) were given 6 h primed, constant intravenous infusions of guanidino-15N2-arginine, 5,5-2H2-citrulline, 15N2-ornithine, and ring-2H5-phenylalanine, in addition to primed, oral doses of U-13C6-arginine in both the fasting and postprandial states. An oral dose of deuterium oxide was also given to determine fat-free mass (FFM). Results: Compared with American women, Indian and Jamaican women had greater ornithine fluxes (µmol · kg fat FFM-1 · h-1) in the fasting and postprandial states (27.3 ± 2.5 vs. 39.6 ± 3.7 and 37.2 ± 2.0, respectively, P = 0.01), indicating greater arginine catabolism. However, Jamaican women had a higher endogenous arginine flux than did Indian and American women in the fasting (66.1 ± 3.1 vs. 54.2 ± 3.1 and 56.1 ± 2.1, respectively, P = 0.01) and postprandial (53.8 ± 2.2 vs. 43.7 ± 4.9 and 42.8 ± 3.1, respectively, P = 0.06) states. As a consequence, Indian women had lower arginine bioavailability (µmol · kg FFM-1 · h-1) in the fasting state (42.0 ± 2.6) than did American (49.9 ± 1.3, P = 0.045) and Jamaican (55.5 ± 3.5, P = 0.004) women, as well as in the postprandial state (40.7 ± 3.5 vs. 51.8 ± 1.2 and 57.5 ± 3.2, respectively, P = 0.001). Conclusion: Compared with American and Jamaican women, Indian women of childbearing age have a decreased arginine supply because of increased arginine catabolism without an increase in arginine flux.
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