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ArtikelIncreased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo  
Oleh: Noakes, Paul S. ; Vlachava, Maria ; Kremmyda, Lefkothea-Stella ; Diaper, Norma D.
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 95 no. 02 (Feb. 2012), page 395-404.
Topik: IMMUNITY; cytokine; pregnancy; immune response; diet; allergens; infant; newborn; interleukin-10; salmon ; immunoglobulin e; treatment outcome; umbilical cord blood; toll-like receptor 2; fatty fish
Fulltext: A07 v95 n2 p395 kelik2022.pdf (291.46KB)
  • Perpustakaan FK
    • Nomor Panggil: A07.K.2012.01
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelBackground: Long-chain n-3 PUFAs found in oily fish may have a role in lowering the risk of allergic disease. Objective: The objective was to assess whether an increased intake of oily fish in pregnancy modifies neonatal immune responses and early markers of atopy. Design: Women (n = 123) were randomly assigned to continue their habitual diet, which was low in oily fish, or to consume 2 portions of salmon per week (providing 3.45 g EPA plus DHA) from 20 wk gestation until delivery. In umbilical cord blood samples (n = 101), we measured n-3 fatty acids, IgE concentrations, and immunologic responses. Infants were clinically evaluated at age 6 mo (n = 86). Results: Cord blood mononuclear cell (CBMC) production of interleukin (IL)-2, IL-4, IL-5, IL-10, and tumor necrosis factor-a in response to phytohemagglutinin (PHA) and of IL-2 in response to Dermatophagoides pteronyssinus allergen 1 (Derp1) was lower in the salmon group (all P = 0.03). In the subgroup of CBMCs in which an allergic phenotype was confirmed in the mother or father, IL-10 production in response to Toll-like receptor 2, 3, and 4 agonists, ovalbumin, salmon parvalbumin, or Derp1 and prostaglandin E2 production in response to lipopolysaccharide or PHA was lower in the salmon group (all P = 0.045). Total IgE at birth and total IgE, incidence and severity of atopic dermatitis, and skin-prick-test positivity at 6 mo of age were not different between the 2 groups. Conclusion: Oily fish intervention in pregnancy modifies neonatal immune responses but may not affect markers of infant atopy assessed at 6 mo of age.
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