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ArtikelContributions of fat and protein to the incretin effect of a mixed meal  
Oleh: Carrel, Guillaume ; Egli, Leonie ; Tran, Christel ; Schneiter, Philippe
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 94 no. 04 (Oct. 2011), page 997-1003 .
Topik: DIABETES; Carbohydrate metabolism
  • Perpustakaan FK
    • Nomor Panggil: A07.K.2011.02
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Isi artikel The American Journal of Clinical NutritionSkip to main page content HOME CURRENT ISSUE EMAIL ALERTS ARCHIVES SUBSCRIPTIONS SEARCH FOR ARTICLES CUSTOM PUBLICATION FAQ Search AJCN Submit Advanced Search Expand+ The American Journal of Clinical First published August 17, 2011, doi: 10.3945/?ajcn.111.017574 Am J Clin Nutr October 2011 vol. 94 no. 4 997-1003 © 2011 American Society for Nutrition Contributions of fat and protein to the incretin effect of a mixed meal1,2,3 Guillaume Carrel, Léonie Egli, Christel Tran, Philippe Schneiter, Vittorio Giusti, David D'Alessio, and Luc Tappy + Author Affiliations 1From the Department of Physiology, University of Lausanne, Lausanne, Switzerland (GC, LE, CT, PS, and LT); Service of Endocrinology, Diabetes and Metabolism, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (VG and LT); and the Division of Endocrinology, University of Cincinnati, Cincinnati, OH (DD) + Author Notes ?2 Supported by grant 310030-121995 from the Swiss National Foundation for Science. ?3 Address correspondence to L Tappy, Faculty of Biology and Medicine, Department of Physiology, Rue du Bugnon 7, CH-1005 Lausanne, Switzerland. E-mail: Abstract Background: The relative contributions of fat and protein to the incretin effect are still largely unknown. Objective: This study assessed the incretin effects elicited by a mixed meal, and by its fat and protein components alone, with the use of a hyperglycemic clamp combined with oral nutrients. Design: Eight healthy volunteers were studied over 6 h after ingestion of a sandwich containing 1) dried meat, butter, and white bread; 2) dried meat alone; 3) butter alone; or 4) no meal (fasting control). Meals were ingested during a hyperglycemic clamp, and the incretin effect was calculated as the increment in plasma insulin after food intake relative to the concentrations observed during the control study. Results: A significant augmentation of postprandial insulin secretion, independent of plasma glycemia, occurred after ingestion of the mixed nutrients and the lipid component of the mixed meal (203 ± 20.7% and 167.4 ± 22.9% of control, respectively; both P < 0.05), whereas the protein component did not induce a significant incretin effect (129.0 ± 7.9% of control; P = 0.6) Conclusions: Fat ingestion, in an amount typical of a standard meal, increases insulin secretion during physiologic hyperglycemia and thus contributes to the incretin effect. In contrast, ingestion of protein typical of normal meals does not contribute to the augmentation of postprandial insulin secretion. This trial was registered at as NCT00869453.
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