Inhibition of Bile Acid Accumulation Decreased The Excessive Hepatocyte Apoptosis and Improved The Liver Secretion Functions on Obstructive Jaundice Patients  

Oleh:

Siregar, Nurjati Chairani ; Lalisang, Toar J. M. ; Sjamsuhidayat, Raden

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Kesehatan vol. 15 no. 1 (Jun. 2011), page 1-5.
Topik: Bile Acids; Hepatocyte Apoptosis. Liver Secretion

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM75.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Excessive hepatpcyte apoptosis induced by bile acid accumulation occured in severe obstructive jaundice,and impair the live secretion function. The objective of this study is to determine whether the inhibition of bile acid accumulation through bile duct decompression affect the excessive hepatocyte apoptosis and caused improvement the liver secretion functions on human model. In this study we use a before and after study on severe obstuctive jaundice patients due to extra hepatic bile duct tumor was decompressed. Bile duct decompression was performed as a model of the role of inhibition of bile acid accumulaton inhibition bile acid accumulation and excessive hepatocyte apoptosis. Bile acid and marker of liver secretion functions were serially measured. Liver biopsy pre and post decompression was performed for Hepatocyte apoptosis pathologic examination by Tunel fluorescing, which measured by 2 people in double bilnded system. Total bile acid, and liver secretionfunctions were measured by automated chemistry analyzer. The result of this study shows that twenty one severe obstructive jaundice patients were included. After decompression the hepatocyte apoptosis index decreased from an average of 53.1 (SD 105) to 11.7 (SD 13.6) (p<0.05). Average of bile acid serum decreased from 96.4 (SD 8.9) to 19.9 (SD 39.5) until 13.0 (SD 12.6) µmo/L (p<0.05) Total bilirubin decreased from 20,0 (SD 8.9) to 13.3 (SD 5.0) until 6.2 (SD 4.0) mg/dL (p<0.05), while the phosphates alkaline (ALP) and glutamil transpeptidase (GT) activities also decreased significantly. In conclusion, bile acids accumulation and excessive hepatocyte apoptosis through bile duct decompression improve the liver secretion functions by inhibition mechanism.

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