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ArtikelLow-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial  
Oleh: Carty, Cara L. ; Kooperberg, Charles ; Neuhouser, Marian L. ; Tinker, Lesley F. ; Howard, Barbara ; Wactawski-Wende, Jean ; Beresford, Shirley A.A. ; Snetselaar, Linda ; Vitolins, Mara ; Allison, Matthew A. ; Budrys, Nicole ; Prentice, Ross ; Peters, Ulrike
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 93 no. 03 (Mar. 2011), page 516-524 .
Topik: NUTRITION; Chronic Disease; Postmenopausal Women; Diatary Intake
Fulltext: Am J Clin Nutr-2011-Carty-516-24.pdf (262.03KB)
  • Perpustakaan FK
    • Nomor Panggil: A07.K.2011.01
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelBackground: The Women's Health Initiative Dietary Modification (DM) Trial was a randomized controlled trial that compared the effects of a low-fat (=20% of total energy) or a usual diet in relation to chronic disease risk in postmenopausal women. Objective: We characterized long-term body-composition changes associated with the DM trial and potential modifiers of these associations. Design: In the DM trial, 48,835 women aged 50–79 y were randomly assigned to intervention (40%) or comparison (60%) groups. We studied a subset with whole-body dual-energy X-ray absorptiometry scans at baseline and during follow-up. Changes in fat mass (FM), lean mass (LM), and percentage body fat between the intervention (n = 1580) and comparison (n = 2731) groups at years 1, 3, and 6 were compared. By using generalized estimating equations, we calculated overall differences between groups and tested for interactions with age, diabetes, race-ethnicity (white, black, and Hispanic), body mass index (BMI), and hormone therapy (HT). Results: The intervention women experienced significantly greater reductions in percentage body fat, FM, and LM at years 1 and 3 than did women in the comparison group (all P < 0.05). At year 6, only the FM change was significantly different between groups. Overall, the intervention was associated with reductions in percentage body fat (-0.8%; 95% CI: -1.0%, -0.6%), FM (-1.1 kg; 95% CI: -1.3, -0.8 kg), and LM (-0.17 kg; 95% CI: -0.28, -0.06 kg) during follow-up (all P < 0.003). Intervention associations varied by race-ethnicity, BMI, diabetes, and HT and remained significant after adjustment for physical activity. Conclusion: This intervention was associated with modest long-term body-composition changes; the findings were more robust in years 1 and 3.
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