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ArtikelNutrition in infancy and long-term risk of obesity: evidence from 2 randomized controlled trials  
Oleh: Singhal, Atul ; Kennedy, Kathy I. ; Lanigan, Julie ; Fewtrell, Mary ; Cole, Tim J ; Stephenson, Terence ; Elias-Jones, Alun ; Weaver, Lawrence T ; Ibhanesebhor, Samuel ; MacDonald, Peter D. ; Bindels, Jacques ; Lucas, Alan
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 92 no. 05 (Nov. 2010), page 1133-1144.
Topik: GROWTH; Development; Pediatrics
Fulltext: Am J Clin Nutr-2010-Singhal-1133-44.pdf (155.4KB)
  • Perpustakaan FK
    • Nomor Panggil: A07.K.2010.02
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelBackground: Growth acceleration as a consequence of relative overnutrition in infancy has been suggested to increase the risk of later obesity. However, few studies have investigated this association by using an experimental study design. Objective: We investigated the effect of early growth promotion on later body composition in 2 studies of infants born small for gestational age (weight <10th percentile in study 1 and <20th percentile in study 2). Design: We reviewed a subset of children (n = 153 of 299 in study 1 and 90 of 246 in study 2) randomly assigned at birth to receive either a control formula or a nutrient-enriched formula (which contained 28–43% more protein and 6–12% more energy than the control formula) at 5–8 y of age. Fat mass was measured by using bioelectric impedance analysis in study 1 and deuterium dilution in study 2. Results: Fat mass was lower in children assigned to receive the control formula than in children assigned to receive the nutrient-enriched formula in both trials [mean (95% CI) difference for fat mass after adjustment for sex: study 1: -38% (-67%, -10%), P = 0.009; study 2: -18% (-36%, -0.3%), P = 0.04]. In nonrandomized analyses, faster weight gain in infancy was associated with greater fat mass in childhood. Conclusions: In 2 prospective randomized trials, we showed that a nutrient-enriched diet in infancy increased fat mass later in childhood. These experimental data support a causal link between faster early weight gain and a later risk of obesity, have important implications for the management of infants born small for gestational age, and suggest that the primary prevention of obesity could begin in infancy.
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