Anda belum login :: 01 Mar 2024 08:50 WIB
Detail
ArtikelInfluence of Thyroid Hormones and Transforming Growth Factor-beta1 on Cystatin C Concentrations  
Oleh: Kotajima, N ; Yanagawa, Y ; Aoki, T
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Journal of International Medical Research vol. 38 no. 04 (Jul. 2010), page 1365-1373.
Topik: cystatin C; Graves' disease; hyperthyroidism; hypothyroidism; thyroid hormone; transforming growth factor-ß1 (TGF-ß1); 3; 5; 3'-tri-iodothyronine (T3); free thyroxine (T4)
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: J11.K.2010.02
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
    Lihat Detail Induk
Isi artikelSerum cystatin C concentrations are reported to increase in the hyperthyroid state. Serum concentrations of cystatin C and transforming growth factor-beta1 (TGF-beta1) were measured in patients with thyroid dysfunction, and the effects of 3,5,3Œ-triiodothyronine (T3) and TGF-beta1 on cystatin C production in human hepatoblastoma (Hep G2) cells were studied. Serum concentrations of cystatin C and TGF-beta1 were significantly higher in patients with Gravesf disease compared with control subjects. Significantly positive correlations were observed between thyroid hormones and cystatin C, thyroid hormones and TGF-beta1, and TGF-beta1 and cystatin C in patients with thyroid dysfunction. Serum concentrations of cystatin C and TGF-beta1 decreased after treatment for hyperthyroidism. Cystatin C mRNA levels and cystatin C secretion were increased by T3 and TGF-beta1 in cultured Hep G2 cells. These results suggest that serum cystatin C concentrations increase in patients with hyperthyroidism. The mechanisms for this may involve elevation of serum TGF-beta1 levels and the stimulatory effects of T3 and TGF-beta1 on cystatin C production.
Opini AndaKlik untuk menuliskan opini Anda tentang koleksi ini!

Kembali
design
 
Process time: 0.03125 second(s)