Anda belum login :: 15 Oct 2024 19:25 WIB
Home
|
Logon
Hidden
»
Administration
»
Collection Detail
Detail
Incretin-based therapies for type 2 diabetes mellitus in Asian patients: Analysis of clinical trials
Oleh:
Louisa, Melva
;
Takeuchi, Madoka
;
Takeuchi, Masahiro
;
Nafrialdi
;
Setiabudy, Rianto
Jenis:
Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi:
Medical Journal of Indonesia vol. 19 no. 03 (Aug. 2010)
,
page 205-212.
Topik:
exenatide
;
incretin
;
liraglutide
;
sitagliptin
;
type-2 diabetes
;
vildagliptin
Fulltext:
Med J Indones 2010-19(205-12).pdf
(160.63KB)
Ketersediaan
Perpustakaan FK
Nomor Panggil:
M35.K.02
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Aim To review the effi cacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population. Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populations. Data pertinent to the effi cacy and safety of GLP-1 mimetics and DPP-4 inhibitors were extracted and used. Results We found 14 randomized controlled trials of incretin based-therapy which included 3567 type 2 diabetes mellitus in Asian population (Japanese, Chinese, Korean, Indian). It was shown that incretin-based therapies improved HbA1c at higher extent (up to -1.42% in exenatide 10 mcg bid, -1.85% for liraglutide 0.9 mg qd, -1.4% for sitagliptin 100 mg and -1.4% for vildagliptin 50 mg bid) compared to the effects observed in studies with Caucasian population, with comparable safety profi le. Conclusion The effi cacy of incretin-based therapies in Asian patients improved glycemic parameters in a higher magnitude on some glycemic parameters compared with those in Caucasian population. These results indicate that incretin-based therapies may be more effective in Asian population than in Caucasian.
Opini Anda
Klik untuk menuliskan opini Anda tentang koleksi ini!
Kembali
Process time: 0.015625 second(s)