Involvement of the nuclear factor-?B pathway in the pathogenesis of endometriosis  

Oleh:

Gonzalez-Ramos, Reinaldo ; Langendonckt, Anne Van ; Defrere, Sylvie

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 94 no. 06 (Nov. 2010), page 1985-1994.
Topik: Angiogenesis; apoptosis; cell proliferation; endometriosis; endometrium; inflammation; invasion; iron; macrophages; NF-kappaB

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2010.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate the role of nuclear factor-?B (NF-?B) in the pathogenesis of endometriosis. Design A literature search was conducted in PubMed to identify all relevant citations. Result(s) Our findings highlight the important role of NF-?B in the pathophysiology of endometriosis. In vitro and in vivo studies show that NF-?B–mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells. Constitutive activation of NF-?B has been demonstrated in endometriotic lesions and peritoneal macrophages of endometriosis patients. Agents blocking NF-?B are effective inhibitors of endometriosis development and some drugs with known NF-?B inhibitory properties have proved efficient at reducing endometriosis-associated symptoms in women. Iron overload activates NF-?B in macrophages. NF-?B activation in macrophages and ectopic endometrial cells stimulates synthesis of proinflammatory cytokines, generating a positive feedback loop in the NF-?B pathway and promoting endometriotic lesion establishment, maintenance and development. Conclusion(s) NF-?B transcriptional activity modulates key cell processes contributing to the initiation and progression of endometriosis. Because endometriosis is a multifactorial disease, inhibiting NF-?B appears to be a promising strategy for future therapies targeting different cell functions involved in endometriosis development, such as cell adhesion, invasion, angiogenesis, inflammation, proliferation, and apoptosis. Upcoming research will elucidate these hypotheses.

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