Efficacy of a Continuous GLP-1 Infusion Compared With a Structured Insulin Infusion Protocol to Reach Normoglycemia in Nonfasted Type 2 Diabetic Patients: A Clinical Pilot Trial  

Oleh:

Sourij, Harald ; Schmolzer, Isabella ; Kettler-Schmut, Eva ; Eder, Michaela

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 32 no. 09 (Sep. 2009), page 1669-1671.
Topik: DIABETES; DIABETES MELLITUS; Continuous GLP-1 Infusion; Structured Insulin Infusion Protocol; Normoglycemia Nonfasted Type 2 Diabetic Patients; A Clinical Pilot Trial

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE : Continuously administered insulin is limited by the need for frequent blood glucose measurements, dose adjustments, and risk of hypoglycemia. Regimens based on glucagon-like peptide 1 (GLP-1) could represent a less complicated treatment alternative. This alternative might be advantageous in hyperglycemic patients hospitalized for acute critical illnesses, who benefit from near normoglycemic control. RESEARCH DESIGN AND METHODS : In a prospective open randomized crossover trial, we investigated eight clinically stable type 2 diabetic patients during intravenous insulin or GLP-1 regimens to normalize blood glucose after a standardized breakfast. RESULTS : The time to reach a plasma glucose below 115 mg/dl was significantly shorter during GLP-1 administration (252 ± 51 vs. 321 ± 43 min, P < 0.01). Maximum glycemia (312 ± 51 vs. 254 ± 48 mg/dl, P < 0.01) and glycemia after 2 h (271 ± 51 vs. 168 ± 48 mg/dl, P = 0.012) and after 4 h (155 ± 51 vs. 116 ± 27 mg/dl, P = 0.02) were significantly lower during GLP-1 administration. CONCLUSIONS : GLP-1 infusion is superior to an established insulin infusion regimen with regard to effectiveness and practicability.

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