Circulating Retinol-Binding Protein 4 and Subclinical Cardiovascular Disease in the Elderly  

Oleh:

Ingelsson, Erik ; Lind, Lars

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 32 no. 04 (Apr. 2009), page 733-735.

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

OBJECTIVE We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS Subclinical CVD was measured with echocardiography, carotid artery ultrasound, brachial artery ultrasound, and invasive forearm endothelial vasoreactivity in 1,008 70-year-old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. RESULTS In analyses adjusted for multiple CVD risk factors, we observed inverse associations of RBP4 with carotid artery intima-media (ß -0.39, 95% CI -0.55 to -0.22) and plaque (ß -0.33, 95% CI -0.60 to -0.05) echogenicity (gray scale median). CONCLUSIONS Circulating RBP4 concentrations were inversely associated with intima-media and plaque echogenicity in carotid arteries. These findings imply that RBP4 could be involved in the development of atherosclerosis.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali