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Circulating Retinol-Binding Protein 4 and Subclinical Cardiovascular Disease in the Elderly
Article from Journal - ilmiah internasional
Diabetes Care vol. 32 no. 04 (Apr. 2009)
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OBJECTIVE We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS Subclinical CVD was measured with echocardiography, carotid artery ultrasound, brachial artery ultrasound, and invasive forearm endothelial vasoreactivity in 1,008 70-year-old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. RESULTS In analyses adjusted for multiple CVD risk factors, we observed inverse associations of RBP4 with carotid artery intima-media (ß -0.39, 95% CI -0.55 to -0.22) and plaque (ß -0.33, 95% CI -0.60 to -0.05) echogenicity (gray scale median). CONCLUSIONS Circulating RBP4 concentrations were inversely associated with intima-media and plaque echogenicity in carotid arteries. These findings imply that RBP4 could be involved in the development of atherosclerosis.
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