Neonatal outcome after vitrified day 3 embryo transfers: a preliminary study  

Oleh:

Raju, Gottumukkala Achyuta Rama ; Prakash, Gomedhikam Jaya ; Krishna, Kota Murali ; Madan, Kalagara

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 92 no. 01 (Jul. 2009), halaman 143-148.
Topik: Day 3 embryos; vitrification; cryoloop; neonatal outcome; congenital birth defects

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective : To compare and evaluate the neonatal outcome in infants born after vitrified day 3 embryo transfers with that of fresh day 3 embryo transfers. Design : Retrospective analysis. Setting : Private assisted reproductive center. Patient(s) : Sixty-nine women, who delivered 89 babies. Intervention(s) : Surplus day 3 cleavage stage embryos were vitrified using ethylene glycol-based solution by cryoloop carrier system and transferred after warming. Main Outcome Measure(s) : Post-thaw survival of embryos, implantation and pregnancy rates (PR), neonatal outcome, and congenital birth defects. Result(s) : A total of 907 vitrified day 3 embryos from 285 cycles were warmed and 817 survived (90.37%), which were used for embryo transfer. The pregnancy, implantation, miscarriage, and live birth rates achieved were 36.84%, 18.11%, 7.71%, and 24.21%, respectively. Of the 69 deliveries, singleton, twins, and triplets comprised of 72.46%, 26.08%, 1.44%, respectively, and 8 (11.59%) were preterm deliveries. The mean Apgar scores were 8.3, 9.2, 9.4 at 1, 5, and 10 minutes. The congenital birth defect rate was 1.18%. These results were comparable with pregnancies using fresh embryo transfers. Conclusion(s) : This preliminary study shows that vitrification is an efficient method of cryopreservation of human day 3 embryos with neonatal outcome comparable to fresh embryo transfers.

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