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Detection of Parallel Functional Modules by Comparative Analysis of Genome Sequences
Article from Journal - ilmiah internasional
Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 2 (Feb. 2005)
parallel functional modules
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Parallel functional modules are separate sets of proteins in an organism that catalyze the same or similar biochemical reactions but act on different substrates or use different co factors. They originate by gene duplication during evolution. Parallel functional modules provide versatility and complexity to organisms, and increase cellular flexibility and robustness. We have developed a fourstep approach for genome wide discovery of parallel modules from protein functional linkages. From ten genomes, we identified 37 cellular systems that consist of parallel functional modules. This approach recovers known parallel complexes and pathways and discovers new ones that conventional homology based methods did not previously reveal, as illustrated by examples of peptide transporters in escherichia coli and nitrogenases in rhodopseudomonas palustris. The approach untangles intertwined functional linkages between parallel functional modules and expand our ability to decode protein functions from genome sequences.
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