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Rescue and Propagation of Fully Retargeted Oncolytic Measles Viruses
Lorimer, Ian A.J.
James, Charles D.
Russell, Stephen J.
Article from Journal - ilmiah internasional
Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 2 (Feb. 2005)
Perpustakaan Pusat (Semanggi)
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Lihat Detail Induk
Live attenuated measles viruses of the edmonston lineage (MV-Edm) have potent anti tumor activity but are not entirely tumors specific owing to widespread distribution of their native receptors, CD46 and SLAM. We have therefore developed a pseudoreceptor sytem that allows rescue and propagation of fully retargeted viruses displaying single chain antibody fragments. Viruses retargeted to tumor selective CD38, epidermal growth factor receptor (EGFR) or EGFR mutant vIII (EGFRvIII) efficiently entered cells through their respective targeted receptors in vitro and in vivo, but not through CD46 and SLAM. When administered intratumorally or interavenously to mice bearing human CD38 or EGFR positive human tumor xenografts, the targeted viruses demonstrated specific receptor mediated anti tumor activity. These data provide an in vivo demonstration of antibody directed tumor destruction by retargeted oncolytic viruses.
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