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ArtikelEffect of 50% Ethanolic Extract of Pegagan Herb (Centella asiatica (L.) Urban) on Cell Proliferation of Lymphocytes in Balb/c Male Mice Induced by Hepatitis B Vaccine  
Oleh: Khusnawati, Nikmah Nur ; Pramono, Suwijiyo ; Sasmito, Ediati
Jenis: Article from Journal - ilmiah internasional - tidak terdaftar di DIKTI
Dalam koleksi: Majalah Obat Tradisional vol. 20 no. 03 (Sep. 2015), page 164-169.
Topik: Centella asiatica (L.) Urban; Asiaticoside; Immunomodulator; Lymphocyte Cells Proliferation
Fulltext: M01 v20 n3 p164 kelik2017.pdf (540.71KB)
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: M01.K
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
    Lihat Detail Induk
Isi artikelPegagan (Centella asiatica (L.) Urban) has been known as multi effect plant that empirically used in the traditional medicine. This research aims to evaluate the effect of 50%ethanolic extract of pegagan herb against increased lymphocyte proliferation cells in Balb/c mice that induced with hepatitis B vaccine, and also to evaluate triterpen glicosida compound (asiaticosida) of 50% ethanolic extract of pegagan herb. The test was done by 60 Balb/c male mices that divided into 6 groups : control group, testing group that was treated with pegagan extract dose of 25 mg/KgBB, 50 mg/KgBB, 100 mg/KgBB, 200 mg/KgBB and 400 mg/KgBB. All of mices were vaccinated on day 0 and days 15. Furthermore, identification of triterpen glicosida compound was done by KLT method using BAW 4:1:5 as upper eluen. Lymphocyte cells were isolated and the cells proliferation measured by MTT reduction method. Data was analyzed statistically using 95% confidence level. The result shown that 50% of ethanolic extract of pegagan herb did not give the immuomodulatory effect while the identification test shown that 50% of extract of pegagan herb has triterpen glicosida compound (asiaticoside).
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