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Effect of 50% Ethanolic Extract of Pegagan Herb (Centella asiatica (L.) Urban) on Cell Proliferation of Lymphocytes in Balb/c Male Mice Induced by Hepatitis B Vaccine
Khusnawati, Nikmah Nur
Article from Journal - ilmiah internasional - tidak terdaftar di DIKTI
Majalah Obat Tradisional vol. 20 no. 03 (Sep. 2015)
Centella asiatica (L.) Urban
Lymphocyte Cells Proliferation
M01 v20 n3 p164 kelik2017.pdf
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Pegagan (Centella asiatica (L.) Urban) has been known as multi effect plant that empirically used in the traditional medicine. This research aims to evaluate the effect of 50%ethanolic extract of pegagan herb against increased lymphocyte proliferation cells in Balb/c mice that induced with hepatitis B vaccine, and also to evaluate triterpen glicosida compound (asiaticosida) of 50% ethanolic extract of pegagan herb. The test was done by 60 Balb/c male mices that divided into 6 groups : control group, testing group that was treated with pegagan extract dose of 25 mg/KgBB, 50 mg/KgBB, 100 mg/KgBB, 200 mg/KgBB and 400 mg/KgBB. All of mices were vaccinated on day 0 and days 15. Furthermore, identification of triterpen glicosida compound was done by KLT method using BAW 4:1:5 as upper eluen. Lymphocyte cells were isolated and the cells proliferation measured by MTT reduction method. Data was analyzed statistically using 95% confidence level. The result shown that 50% of ethanolic extract of pegagan herb did not give the immuomodulatory effect while the identification test shown that 50% of extract of pegagan herb has triterpen glicosida compound (asiaticoside).
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