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Hepatoprotective and Nephroprotective Effects of Avocado Seeds Against Carbon Tetrachloride in Rats
Perwita, Ni Luh Putu Dian
Quraisyin, Yuditha Anggarhani
Article from Journal - ilmiah internasional - tidak terdaftar di DIKTI
Majalah Obat Tradisional vol. 19 no. 03 (Sep. 2014)
M01 v19 n3 p133 kelik2017.pdf
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The aim of this research to investigate the hepatoprotective and nephroprotecitve effects of Avocado seeds against carbon tetrachloride in rats. The rats was treated with the infusion and decoction of avocado seeds at doses 360.7, 642.1, 1142,9 mg/kg per oral once in a day for 6 days and carbon tetrachloride (2mL/kg) was given on the 7th day. Blood sample from all groups was obtained by sinus orbitalis after 24 hours application for the serum transaminase and creatinine. The increasing of serum transaminase and creatinine in carbon tetrachloride-treated rats, were significantly decreased (p<0.05) with both pretreatment of infusion and decoction of avocado seeds. Based on the research, it can be concluded that infusion and decoction of avocado seeds have a potent protective action upon carbon tetrachloride-induced hepatic and renal damage in rats.
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