Anda belum login :: 29 Feb 2024 14:43 WIB
Detail
ArtikelChemical Constituens of an Endophytic Fungus Aspergillus Sp (Sbd5) Isolated from Sambiloto (Andrographis paniculata Nees)  
Oleh: Elfita ; Munawar ; Muharni ; Ivantri, Ihsan
Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Microbiology Indonesia vol. 9 no. 2 (Jun. 2015), page 82-88.
Topik: Andrographis paniculata; antibacterial activity; chemical constituens; endophytic fungus
Fulltext: 322-936_her.pdf (1.47MB)
Isi artikelMedicinal plants and their endophytes are important resources for discovery of natural products. Endophytic fungi isolated from medicinal plants more likely exibit pharmaceutical potentials. In the present study, an endophytic fungus Aspergillus sp (SbD5) was isolated from leaves of sambiloto (Andrographis paniculata). The fungus isolate was cultivated in Potato Dextrose Broth (PDB) medium for 7 weeks in static, then extracted with ethyl acetate followed by Thin Layer Chromatography (TLC) test. The results displayed three major spots. Ethyl acetate extract was further separated by column chromatography and recrystallization to obtain three pure compounds. Their structures were determined on the basic of spectroscopic analysis. The compounds is one new benzochromen derivative, 1-(3,8-dihydroxy-4,6,6-trimethyl-6H- benzochromen-2-yloxy)propan-2-one (1), together with two known compounds 5-hydroxy-4-(hydroxymethyl)-2H-pyran-2-one (2) and (5-hydroxy-2oxo-2H-pyran-4-yl)methyl acetate (3). The antibacterial activities of the compounds were tested using the disc diffusion method against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Shigella dysenteriae and Salmonella typhi. Compound 1 has the highest antibacterial activity followed by compound 2 and 3.
Opini AndaKlik untuk menuliskan opini Anda tentang koleksi ini!

Kembali
design
 
Process time: 0.0625 second(s)