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Angiotensin-converting Enzyme Gene Polymorphisms, Blood Pressure and Pulse Pressure in Subjects with Essential Hypertension in a South Sulawesi Indonesian Population
Article from Journal - ilmiah nasional - terakreditasi DIKTI
Acta Medica Indonesiana vol. 44 no. 4 (Oct. 2012)
ACE gene polymorphism
Angiotensin-converting Enzyme Gene Polymorphisms.pdf
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Aim: to investigate the potential association between the ACE gene polymorphism, essential hypertension and pulse pressure. Methods: the study included 99 non-hypertensive and 104 hypertensive subjects. Hypertension is defined as systolic blood pressure =140 mmHg and/or diastolic blood pressure =90 mmHg. Pulse pressure refers to the differences between the systolic blood pressure and diastolic blood pressure. DNA amplication to examine ACE I/D polymorphism was conducted by Rigat-modification PCR method. Results: this study showed no significant difference in genotype distribution and allele frequency between two groups. We found PP >60 mmHg is different between ACE gene genotype. Genotype DD has a risk of 1.8 times of having PP >60 mmHg than ID genotype while DD genotype has a risk of 4.4 times of having PP >60mg than II genotype. Conclusion: this study does not support that the I/D polymorphism at ACE gene locus associated with hypertension in Makassar, South-Sulawesi, Indonesia. However, there were a significant correlation with pulse pressure independent from blood pressure.
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