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Ethanolic extract of Anredera cordifolia (Ten.) Steenis leaves improved wound healing in guinea pigs
Prabowo, Bayu Rizky
Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Universa Medicina vol. 31 no. 01 (Jan. 2012)
Anredera cordifolia (Ten.) Steenis
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BACKGROUND Wound healing is a normal biological process in response to skin injury.Anredera cordifolia (Ten.) Steenis is used traditionally to treat various diseases,including skin disease, hypertension, inflammation and gout. The aim of thisstudy was to evaluate the wound healing activity of the leaves of binahong orAnredera cordifolia (Ten.) Steenis in guinea pigs. METHODS Thirty guinea pigs (1.5-2 kg, 3-4 months old) were randomly divided into 5groups. Group I was given distilled water (negative control), group II wastreated with povidone iodine 10% (positive control), while groups III-V weretreated with ethanolic extract of binahong leaves at concentrations of 10%,20%, and 40%, respectively. Before treatment, a 2 cm long excision woundwas made on each animal. All interventions were given by the topical route,twice daily for 15 days. At the end of 15th day, the wound lengths in each groupwere measured and compared to baseline wound lengths. Data were analyzedwith one-way Anova to compare wound healing activity between groups. RESULTS This study showed that groups treated with ethanolic extract of binahong leavesat concentrations of 20% and 40% experienced better wound healing activitythan negative and positive controls. There were significant differences (p=0.000)between treatments and negative and positive controls. CONCLUSIONS This research has succesfully show significance of the Binahong leaf extracthas a potential for wound healing in guinea pig.
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