Topiramate sprinkle is effective in the treatment of childhood epilepsy  

Oleh:

Gunawan, Prastiya Indra ; Saharso, Darto

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Universa Medicina vol. 31 no. 01 (Jan. 2012), page 34-42.
Topik: Topiramate sprinkle monotherapy; seizure frequency; side effect; childhood
Fulltext: Prastiya-Indra-Gunawan1.pdf (223.88KB)

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Perpustakaan FK Nomor Panggil: U01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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BACKGROUND Epilepsy remains one of the most frequently occurring pediatric problems.Approximately 10-15% patients do not respond to conventional therapy.Topiramate as a novel antiepileptic drug has a broad spectrum activity,presumably indicative of multiple anti-seizure mechanisms. Previous studiesof topiramate as adjunctive and monotherapy in adults have shown beneficialeffects. The objective of this research was to evaluate the efficacy and tolerabilityof topiramate sprinkle monotherapy in pediatric epilepsy. METHODS This experimental research was conducted in the Pediatric Neurology outpatientclinic department, Soetomo hospital, Surabaya, involving 18 consecutivesubjects. Subjects meeting the inclusion criteria were treated with topiramatesprinkle adjusted dose. Seizure frequency and side effects were observed inweeks 1, 4, 8, 12, 16, 20 and 24, respectively. Electro encephalogram (EEG)and laboratory examinations were performed prior to and after 6 months oftreatment. The t-test for related samples and McNemar test were utilized forstatistical analysis. RESULTS A total of 15 subjects completed the study. Topiramate-treated patients showeda statistically significant difference of seizure frequency reduction from 2.7 ±1.16 to 0.13 ± 0.51 (p=0.000) with 93.7% patients being seizure free in 20weeks. EEG recordings did not differ statistically in decrement of epileptiformactivity in 20% subjects. About 7% subjects developed drowsiness and 33.3%subjects suffered from appetite suppression in the initial treatment. Laboratoryresults showed no abnormalities. CONCLUSIONS There was reduction of seizure frequency and no EEG recording alterationsafter topiramate sprinkle monotherapy. Topiramate as a monotherapy is highlyeffcicacious in childhood epilepsy.

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