Zinc supplementation could modulate T cell to maintain interleukin-2 level in seropositive contact of leprosy patients  

Oleh:

Ludin, Mohammad Z. Rahfi ; Wirjatmadi, Bambang ; Agusni, Indropo

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 20 no. 3 (Aug. 2011), page 201-204.
Topik: IgM anti phenolic glycolipid-1; seropositive leprosy
Fulltext: Volume 20, Issue 3, August 2011 - Zinc supplementation could modulate T cell to maintain interleukin-2 level in seropositive contact of leprosy patients.pdf (90.2KB)

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Perpustakaan FK Nomor Panggil: M35.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Abstract Background: WHO classifi ed the number of leprosy cases in Indonesia as number three in the world after India and Brazil. The number of new leprosy patients tends to increase since there is a possibility that seropositive leprosy is turning into manifest leprosy. The aim of this study was to analyze the infl uence of zinc supplementation on interleukin-2 (IL-2) level of seropositive contact of leprosy patients with marginal zinc defi ciency. Methods: Twenty two subjects aged 20-40 years were recruited for this study. The zinc-supplemented group received 40 mg elemental Zn/d orally for 3 months. Seropositive leprosy was determined by examining IgM anti Phenolic Glycolipid–1 level and concentration of IL-2 in lymphocyte cell culture supernatant fl uid were measured by Elisa method. Results: The IL-2 concentration in the subject in the zinc group was relatively not changed (p= 0.721), whereas that in placebo group tended to be signifi cantly lower (p= 0.025) at the end of the study. Conclusion: There was a signifi cant change of IL-2 level between both groups (p= 0.037).

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