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ArtikelIron and folic acid supplements in pregnancy improve child survival in Indonesia  
Oleh: Dibley, Michael J. ; Titaley, Christiana R ; d'Este, Catherine ; Agho, Kingsley
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 95 no. 01 (Jan. 2012), page 220-230 .
Topik: NUTRITION; Iron-folic Acid; Early Neonatal Death
Fulltext: A07 v95 n1 p220 kelik2022.pdf (483.17KB)
  • Perpustakaan FK
    • Nomor Panggil: A07.K.2012.01
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelBackground: Several trials have shown that iron-folic acid supplements during pregnancy protect newborns against preterm delivery and early neonatal death, but the impact beyond the neonatal period is unclear. Objective: We determined whether live-born children <5 y of age born to mothers who used antenatal iron-folic acid supplements had reduced risk of death. Design: Pooled 1994, 1997, 2002–2003, and 2007 Indonesia Demographic and Health Survey data were used to examine the relation between the use of iron-folic acid supplements and child death in 3 cumulative (0–30 d, 0–11 mo, and 0–4 y) and 4 mutually exclusive (first day of life and 1–30 d, 1–11 mo, and 1–4 y of age) time periods. Risk of death was estimated by using Cox regression to control for 19 potential confounders. Results: Survival information for 52,917 singleton live-born infants and 1525 deaths of children <5 y of age was examined. After adjustment for potential confounders, risk of death of children <5 y of age was reduced significantly by 34% if the mother consumed any iron-folic acid supplements [adjusted HR (aHR): 0.66; 95% CI: 0.53, 0.81; P < 0.001]. This protective effect was greatest for deaths on the first day of life (aHR: 0.40; 95% CI: 0.21, 0.77; P = 0.005) but was also shown for neonatal deaths on days 1–30 of life (aHR: 0.69; 95% CI: 0.49, 0.97; P = 0.035) and postneonatal deaths (aHR: 0.74; 95% CI: 0.56, 0.99; P = 0.044). There was a strong dose response of greater protection from death of children <5 y of age with increasing numbers of iron-folic acid supplements consumed. Conclusion: In developing countries increased use of antenatal iron-folic acid supplements will reduce deaths of children <5 y of age, especially in the first year of life.
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