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Secondhand tobacco smoke exposure is associated with increased risk of failed implantation and reduced IVF success
Oleh:
Benedict, Merle D.
;
Missmer, Stacey A.
;
Vahratian, Anjel
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
Human Reproduction vol. 26 no. 09 (Sep. 2011)
,
page 2525-2531..
Topik:
REPRODUCTIVE EPIDEMIOLOGY
;
Environmental Tobacco Smoke
;
Cotinine
;
Assisted Reproduction In Vitro Fertilization
;
Follicular Fluid
Fulltext:
Hum. Reprod.-2011-Benedict-2525-31.pdf
(130.59KB)
Ketersediaan
Perpustakaan FK
Nomor Panggil:
H07.K.2011.02
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
BACKGROUND Infertility and early pregnancy loss are prevalent as is exposure to secondhand tobacco smoke (STS). Previous research has suggested a relationship between STS exposure and early pregnancy loss, but studies have been limited by small study sizes and/or imprecise methods for exposure estimation. IVF allows for the collection of follicular fluid (FF), the fluid surrounding the pre-ovulatory oocyte, which may be a more biologically relevant sample media than urine or serum in studies of early reproduction. METHODS In a retrospective analysis of a prospective cohort study, we measured cotinine in FF collected during 3270 IVF treatment cycles from 1909 non-smoking women between 1994 and 2003 to examine the relationship between STS exposure and implantation failure. RESULTS In adjusted models, we found a significant increase in the risk of implantation failure among women exposed to STS compared with those unexposed [odds ratio (OR) = 1.52; 95% confidence interval (CI) = 1.20–1.92; risk ratio (RR) = 1.17; 95% CI = 1.10–1.25]. We also found a significant decrease in the odds for a live birth among STS-exposed women (OR = 0.75; 95% CI = 0.57–0.99; RR = 0.81; 95% CI = 0.66–0.99). CONCLUSIONS Female STS exposure, estimated through the measurement of cotinine in FF, is associated with an increased risk of implantation failure and reduced odds of a live birth.
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