Does Estrogen Protect Against Cognitive Aging in Women?  

Oleh:

Sherwin, Barbara B.

Jenis: Article from Journal - e-Journal
Dalam koleksi: Current Directions in Psychological Science vol. 16 no. 05 (Oct. 2007), page 275-279.
Topik: Estrogen; Cognition; Aging; Postmenopausal Women
Fulltext: 09. Does Estrogen Protect Against Cognitive Aging in Women.pdf (112.91KB)

Isi artikel

Although there is evidence from randomized controlled trials that estrogen therapy protects against aspects of cognitive decline that occur with normal aging in women, findings from the Women’s Health Initiative Memory Study and from some cross-sectional and longitudinal studies failed to find neuroprotective effects of estrogen in older women. There is growing empirical support for the critical-period hypothesis, formulated in the attempt to resolve these discrepancies. It holds that estrogen therapy has protective effects on verbal memory and on working memory only when it is initiated closely in time to menopause, whereas starting treatment many years following menopause does not protect and may even be harmful. Supporting evidence for this hypothesis from basic neuroscience and from animal and human studies is evaluated for its ability to explain the inconsistencies and to describe the conditions under which estrogen may protect cognitive function in aging women.

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