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Circulating CD56+ cells of diabetic women show deviated homing potential for specific tissues during and following pregnancy
Article from Journal - ilmiah internasional
Human Reproduction vol. 26 no. 07 (Jul. 2011)
Uterine Natural Killer Cells
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BACKGROUND Human uterine natural killer (uNK) cells, the dominant lymphocytes in early pregnancy decidua, are important for spiral arterial remodelling. uNK cells are thought to arise from circulating CD56bright NK cells that egress into decidualizing endometrium. Both incomplete spiral arterial modification and aberrant NK cell function have been linked with pre-eclampsia, a syndrome that is more prevalent in diabetic women. Since previous in vitro studies have shown that changes in decidual endothelium induced by type 1 diabetes (T1D) reduce its interactions with circulating leucocytes, we hypothesized that diabetes additionally has direct effects on circulating CD56+ NK cells that impair their decidual homing potential. METHODS Serial blood samples were collected from control, T1D and T2D pregnant women throughout and after pregnancy. In vitro adhesion under shear forces was used to assay the functional capacity of circulating leucocytes and of CD56+ cells to adhere to endothelium in cryostat sections of gestation day (gd) 7 normal mouse decidua, pancreas and lymph node. RESULTS Fewer CD56+ cells from diabetic compared with control women adhered to normal decidual endothelium. The CD56+ cell/total cell adhesion ratio was also lower in diabetics. More diabetic CD56+ cells adhered to pancreatic endothelium and their proportion was greater than for controls. Neither absolute nor proportional adhesion of CD56+ cells to lymph node endothelium differed between diabetics and controls. CONCLUSIONS The CD56+ cell adhesion patterns of T1D and T2D women differ from those of non-diabetic women and support the hypothesis that diabetes impairs mechanisms that could be used by CD56+ cells for egress into decidua.
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