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ArtikelInvestigation of the possibility of using ischemia-modified albumin in testicular torsion: an experimental study  
Oleh: Kutlu, Omer ; Mentese, Ahmet ; Turkmen, Suha ; Turedi, Suleyman ; Gunduz, Abdulkadir ; Yulug, Esin ; Alver, Ahmet ; Karahan, Suleyman Caner
Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 04 (Mar. 2011), page 1333-1337.
Topik: EXPERIMENTAL STUDY; Testicular torsion; ischemia-modified albumin; oxidative stress
Ketersediaan
  • Perpustakaan FK
    • Nomor Panggil: F02.K.2011.03
    • Non-tandon: 1 (dapat dipinjam: 0)
    • Tandon: tidak ada
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Isi artikelObjective To investigate the serum ischemia-modified albumin levels with use of an experimental testicular torsion (TT) model. Design Randomized, controlled experimental study. Setting University hospital. Animal(s) Thirty mature male Wistar rats. Intervention(s) Rats were divided into five groups: a sham operation group, 2- and 4-hour control (groups I and III, respectively), and 2- and 4-hour torsion groups (groups II and IV, respectively). Ischemia-modified albumin, tissue and blood malondialdehyde (MDA), tissue and blood myeloperoxidase (MPO) activity levels, and histopathologic damage scores then were compared. Main Outcome Measure(s) Ischemia-modified albumin, tissue and blood MDA, tissue and blood MPO activity levels, and histopathologic damage scores. Result(s) There was a significantly higher level of histopathologic damage in the 4-hour torsion group, and the serum ischemia-modified albumin levels in this group were significantly higher than those of the other groups. There was no difference between the groups in terms of blood and tissue MDA and MPO levels. There was no significant correlation between ischemia-modified albumin levels and blood and tissue MDA and MPO levels. The only significant correlation between histopathologic score and biochemical markers was that with blood and tissue MPO. Conclusion(s) The results from this pioneering study determined a high level of ischemia-modified albumin in TT, indicating a potential value for TT diagnosis. The value of ischemia-modified albumin levels in TT should be investigated also with respect to prognosis.
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