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Postoperative inflammation in the abdominal cavity increases adhesion formation in a laparoscopic mouse model
Binda, Maria Mercedes
Koninckx, Philippe R.
Article from Journal - ilmiah internasional
Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 95 no. 04 (Mar. 2011)
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Objective To investigate acute inflammation in the peritoneal cavity in adhesion formation. Design Prospective randomized, controlled trial. Setting University laboratory research center. Animal(s) 9- to 10-week-old BALB/c female mice. Intervention(s) In a laparoscopic mouse model, acute inflammation in the peritoneal cavity evaluated in CO2 pneumoperitoneum enhaced adhesions, by CO2 pneumoperitoneum plus manipulation, and in the latter group plus dexamethasone. Main Outcome Measure(s) Qualitative and quantitative adhesion scores and an acute inflammation score (neoangiogenesis, diapedesis, and leukocyte accumulation). Result(s) Adhesions at the lesion site were enhanced by the CO2 pneumoperitoneum, further enhanced by manipulation, and decreased by the administration of dexamethasone. The acute inflammation scores (total, neoangiogenesis, diapedesis, and leukocyte accumulation) strongly correlated with the total adhesion score. Inflammation scores were similar at both the surgical lesion and the parietal peritoneum. Conclusion(s) Acute inflammation of the entire peritoneum cavity is an important mechanism involved in adhesion formation and enhances adhesion formation at the lesion site.
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