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Hereditary thrombophilia and recurrent pregnancy loss: a retrospective cohort study of pregnancy outcome and obstetric complications
Oleh:
Lund, M.
;
Nielsen, H.S.
;
Hviid, T.V.
;
Steffensen, R.
;
Andersen, Anders Nyboe
;
Christiansen, Ole B.
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
Human Reproduction vol. 25 no. 12 (Dec. 2010)
,
page 2978-2984 .
Topik:
EARLY PREGNANCY
;
pregnancy-induced hypertension
;
pre-eclampsia
;
intrauterine growth restriction
;
antiplatelet therapy
;
Fulltext:
Human Reproduction, Vol.25, No.12 pp. 2978–2984, 2010.pdf
(134.13KB)
Ketersediaan
Perpustakaan FK
Nomor Panggil:
H07.K.2010.04
Non-tandon:
1 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
BACKGROUND Low-dose aspirin therapy could improve remodelling of maternal spiral arteries during early placentation and prevent subsequent pregnancy-related hypertensive disorders. We investigated whether low-dose aspirin therapy reduces the incidence of hypertensive pregnancy complications in unselected IVF and ICSI patients when medication was started prior to pregnancy. METHODS A total of 487 patients who underwent IVF/ICSI were randomized to receive 100 mg aspirin (n = 242) or placebo (n = 245) daily, starting on the first day of gonadotrophin stimulation. Pregnant women continued the medication until delivery. A total of 107 patients (52 with aspirin and 55 with placebo) experienced live birth and were included in this follow-up study. The main outcome measure was the incidence of hypertensive pregnancy complications. RESULTS Embryo transfer took place in 227 (94%) women in the aspirin group and in 229 (93%) women in the placebo group. The live birth rate between the aspirin (22.9%) and placebo (24.0%) groups did not differ significantly (P = 0.78). The overall incidence of hypertensive pregnancy complications was 15.4% (8/52) in the aspirin group and 18.2% (10/55) in the placebo group (P = 0.70, 95% confidence interval for the difference of proportions -17 to 11%). There were two cases of severe pre-eclampsia in the aspirin group and three cases in the placebo group. CONCLUSIONS In the present study, the incidence of hypertensive pregnancy complications did not differ statistically significantly between low-dose aspirin and placebo groups in unselected IVF/ICSI patients, when medication was started concomitantly with gonadotrophin stimulation and continued until delivery.
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