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Effect of L-dopa on interleukin-1ß-induced suppression of luteinizing hormone secretion in intact female rats
Article from Journal - ilmiah internasional
Human Reproduction vol. 24 no. 03 (Mar. 2009)
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BACKGROUND: The cytokine, interleukin-1ß (IL-1ß), increases during immune stress and is known to suppress the preovulatory luteinizing hormone (LH) surge in female rats by decreasing hypothalamic norepinephrine (NE). We hypothesized that IL-1ß could produce this effect by decreasing NE biosynthesis. METHODS: Female Sprague–Dawley rats were implanted with a push–pull cannula in the medial preoptic area (MPA) of the hypothalamus and a catheter in the jugular vein. They were treated i.p. with the vehicle or 5 µg of IL-1ß, the NE precursor, L-dopa, or a combination of L-dopa and IL-1ß at 1300 hours on the day of proestrus. They were subjected to push–pull perfusion and serial blood sampling. Perfusates were analyzed for NE levels and serum samples for LH. RESULTS: IL-1ß treatment blocked the increase in NE levels in the MPA and the LH surge. Treatment with L-dopa was able to partially restore both NE and LH levels during the afternoon of proestrus. IL-1ß treatment caused failure of ovulation and this effect was also reversed by L-dopa. CONCLUSIONS: These results suggest that IL-1ß could decrease NE levels in the MPA to suppress reproductive functions and L-dopa can be used to counter this effect.
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