Stomach cancer in 67 Chinese counties: evidence of interaction between salt consumption and helicobacter pylori infection  

Oleh:

Xiaoqin, Wang ; Terry, Paul M. ; Yan, Hong

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Asia Pacific Journal of Clinical Nutrition (keterangan: ada di Proquest) vol. 17 no. 04 (2008), page 644.
Topik: helicobacter pylori; stomach cancer; mortality; urinary nitrate; urinary sodium

Ketersediaan

Perpustakaan FK Nomor Panggil: A27.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective: To examine the interaction between salt-intake and helicobacter pylori (H. pylori) infection in the development of stomach cancer in an ecological study of 67 Chinese rural counties. Methods: Stomach cancer mortality data of 67 counties were derived from a national survey conducted in China between 1986 and1988. Information regarding the prevalence of H. pylori infection and urinary sodium excretion were collected from the same individuals during a subsequent dietary survey in 1989. Results: In these 67 counties, H. pylori prevalence and urinary sodium were correlated with stomach cancer mortality, with r=0.31 (p=0.01) and r=0.28 (p=0.03), respectively. After stratification, the significant correlation between H. pylori prevalence and stomach cancer mortality only existed in counties with high levels (³5.0 mg/mg creatinine/12-hour) of urinary sodium (r=0.5; p=0.002). Similarly, the significant correlation between urinary sodium and stomach cancer mortality was only presented in counties with high (³71.6%) H. pylori prevalence (r=0.4; p=0.017). Multivariate regression analysis showed results consistent with the correlation analysis. Conclusion: These findings suggest that there may be an interaction between high salt consumption and H .pylori infection in the development of stomach cancer. Corroborating data from epidemiological, clinical, and experimental studies are needed.

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