Whey Protein Ingestion Enhances Postprandial Anabolism during Short-Term Bed Rest in Young Men  

Oleh:

Antonione, Raffaella ; Caliandrom, Elena ; Zorat, Francesca ; Guarnieri, Gianfranco ; Heer, Martina ; Biolo, Gianni

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: JN: The Journal of Nutrition vol. 138 no. 11 (Nov. 2008), page 2212.
Topik: Nutrient Physiology; Metabolism; and Nutrient-Nutrient Interactions

Ketersediaan

Perpustakaan FK Nomor Panggil: J42.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

We tested the relative ability of rapidly digested whey and slowly digested casein to stimulate net whole-body protein synthesis during prolonged physical inactivity. We studied 8 young male volunteers after they consumed isonitrogenous casein or whey mixed meals on d 12 or d 14 of experimental bed rest. Rates of phenylalanine hydroxylation were measured by primed-constant oral administration of L[2-2H2]tyrosine and L[ring-2H5]phenylalanine for 3 h in the postabsorptive state and 6 h after an isonitrogenous bolus meal containing sucrose (0.27 g/kg) and casein or whey (0.40 g/kg). Net protein synthesis in the fed state was calculated during the first 6 h postmeal as the difference between phenylalanine hydroxylation and phenylalanine content in the ingested casein or whey. In the fed state, the integrated changes in phenylalanine hydroxylation were lower (P < 0.05) after whey (–2 ± 8 µmol·kg–1·6 h–1) than after casein ingestion (34 ± 7 µmol·kg–1·6 h–1). During bed rest, net postprandial protein synthesis was greater (P < 0.05) after whey (96 ± 8 µmol phenylalanine·kg–1·6 h–1) than after casein ingestion (82 ± 7 µmol phenylalanine·kg–1·6 h–1). The rapidly digested whey protein was more efficient than the slowly digested casein in increasing postprandial net protein synthesis during short-term bed rest.

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