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Asthma symptoms improvment in moderate persistent asthma patients with gastroesophageal reflux disease (GERD): the role of proton-pump inhibitor
Susanto, Agus Dwi
Wiyono, Wiwien Heru
Lelosutan, Syafrudin AR
Article from Journal - ilmiah nasional - terakreditasi DIKTI
Medical Journal of Indonesia vol. 17 no. 03 (Jul. 2008)
moderate persistent asthma
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The study aimed to evaluate effect of proton pump inhibitor (esomeprazole) on asthma with gastroesofageal refluks disease (GERD). This randomized single blind, controlled clinical trial was conducted at Persahabatan Hospital, Jakarta from July 2004 until October 2005. Samples were moderate persistent asthma patients with GERD. GERD is dianosed GERD symptoms and proof of oesophagitis from endoscopy and or histapatologic examination from oesophagus biopsy. Phase 1:2 week run-in period patient received inhaled budesonide 2x200 ug/day. phase 2: patient randomised to receive inhaled budesonide 2 x 400 ug/day with esomeprazole 40mg/day or without esomeprazole (control group) for 8 week. Phase 3:4 week wash out period, patient receive inhaled budesonide 2 x 200 ug/day. Diary cards were assessed at run-in periode, after treatment 4 weeks, 8 weeks and wast out . There were 32 patients ( 23 female and 9 male) completed the study. Mean total asthma symptoms score daily were significantly decresed on eso,eprazole vs without esomeprazole after 8 weeks (-2.29 vs -0.90; p<0.05. Mean use of inhaled bronchodilator was significantly descreased on esomeprazole vs without esomeprazole after 8 week (-1,09 vs -0.42;p<0.05). Morning and evening PEFR improved higher on esomeprazole than without esomeprazol but were not significantl differece. In conclusion, administration esomeprazole 40 mg daily improved asthma syptoms and lower the use of inhaled bronchodilator in moderate persistant asthma patients with GERD.
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