Phylloquinone intake, insulin sensitivity, and glycemic status in men and women  

Oleh:

Yoshida, Makiko ; Booth, Sarah L ; Meigs, James B. ; Saltzman, Edward ; Jacques, Paul F.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 88 no. 01 (Jul. 2008), page 210.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: Limited evidence suggests that vitamin K may have a beneficial role in glucose homeostasis. No observational data exist on the associations between vitamin K intake and insulin sensitivity. Objective: We aimed to examine associations between vitamin K intake and measures of insulin sensitivity and glycemic status in men and women aged 26–81 y. Design: We assessed the cross-sectional associations of self-reported phylloquinone (vitamin K1) intake with insulin sensitivity and glycemic status in the Framingham Offspring Cohort. Dietary and supplemental phylloquinone intakes were assessed by using a food-frequency questionnaire. Insulin sensitivity was measured by fasting and 2-h post-oral-glucose-tolerance test (OGTT) insulin, the homeostasis model assessment of insulin resistance (HOMA-IR), and the insulin sensitivity index (ISI0,120). Glycemic status was assessed by fasting and 2-h post-OGTT glucose and glycated hemoglobin (HbA1c). Results: Higher phylloquinone intake was associated with greater insulin sensitivity and glycemic status, as measured by 2-h post-OGTT insulin and glucose and ISI0,120, after adjustment for age, sex, waist circumference, lifestyle characteristics, and diet quality [2-h post-OGTT insulin: lowest and highest quintile, 81.0 and 72.7 µU/mL, respectively (P for trend = 0.003); 2-h post-OGTT glucose: 106.3 and 101.9 mg/dL, respectively (P for trend = 0.009); ISI0,120: 26.3 and 27.3 mgL2/mmolmUmin (P for trend = 0.009)]. Phylloquinone intake was not associated with fasting insulin and glucose concentrations, HOMA-IR, or HbA1c. Conclusion: Our findings support a potential beneficial role for phylloquinone in glucose homeostasis in men and women.

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