Anda belum login :: 16 Aug 2022 01:09 WIB
Widespread Monoallelic Expression on Human Autosomes
Hutchinson, John N.
Thompson, Benjamin R.
Article from Bulletin/Magazine
SCIENCE (keterangan: ada di Proquest) vol. 318 no. 5853 (Nov. 2007)
1 (dapat dipinjam: 0)
Lihat Detail Induk
Monoallelic expression with random choice between the maternal and paternal alleles defines an unusual class of genes comprising X-inactivated genes and a few autosomal gene families. Using a genome-wide approach, we assessed allele-specific transcription of about 4000 human genes in clonal cell lines and found that more than 300 were subject to random monoallelic expression. For a majority of monoallelic genes, we also observed some clonal lines displaying biallelic expression. Clonal cell lines reflect an independent choice to express the maternal, the paternal, or both alleles for each of these genes. This can lead to differences in expressed protein sequence and to differences in levels of gene expression. Unexpectedly widespread monoallelic expression suggests a mechanism that generates diversity in individual cells and their clonal descendants.
Klik untuk menuliskan opini Anda tentang koleksi ini!
Copyright © 2006, 2007
Unika Atma Jaya
, all rights reserved
Process time: 0.0312518 second(s)