Detail Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity   Oleh:  Berghuis, Paul ; Rajnicek, Ann M. ; Morozov, Yury M. ; Ross, Ruth A. ; Mulder, Jan ; Urban, Gabriella M ; Monory, Krisztina ; Marsicano, Giovanni ; Matteoli, Michela ; Canty, Alison ; Irving, Andrew J ; Katona, Istvan ; Yanagawa, Yuchio ; Rakic, Pasko ; Lutz, Beat ; Mackie, Ken ; Harkany, Tibor Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5828 (May 2007), page 1212. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CBl cannabinoid receptors (CBlRs) are enriched in the axonal growth cones of y-aminobutyric acid-containing (GABAergid interneurons in the rodent cortex during late gestation. Endocannabinoids trigger CBlR internalization and elimination from filopodia and induce chemorepulsion and collapse of axonal growth cones of these GABAergic interneurons by activating RhoA. Similarly, endocannabinoids diminish the galvanotropism of Xenopus laevis spinal neurons. These findings, together with the impaired target selection of cortical GABAergic interneurons lacking CBlRs, identify endocannabinoids as axon guidance cues and demonstrate that endocannabinoid signaling regulates synaptogenesis and target selection in vivo Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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