Detail How Synaptotagmin Promotes Membrane Fusion   Oleh:  Martens, sascha ; Kozlov, Michael M ; McMahon, Harvey T Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5828 (May 2007), page 1205. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Synaptic vesicles loaded with neurotransmitters are exocytosed in a soluble N-ethylmaleimide¬sensitive factor attachment protein receptor (SNARE)-dependent manner after presynaptic depolarization induces calcium ion (Caz+) influx. The Caz+ sensor required for fast fusion is synaptotagmin-l. The activation energy of bilayer-bilayer fusion is very high (",40 kBT>. We found that, in response to Caz+ binding, synaptotagmin-l could promote SNARE-mediated fusion by lowering this activation barrier by inducing high positive curvature in target membranes on C2¬domain membrane insertion. Thus, synaptotagmin-l triggers the fusion of docked vesicles by local Caz+-dependent buckling of the plasma membrane together with the zippering of SNAREs. This mechanism may be widely used in membrane fusion. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved