Age at Surgery for Undescended Testis and Risk of Testicular Cancer  

Oleh:

Pettersson, Andreas ; Richiardi, Lorenzo ; Nordenskjold, Agneta ; Kaijser, Magnus ; Akre, Olof

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 356 no. 18 (May 2007), page 1835.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND Undescended testis, which is a risk factor for testicular cancer, is usually treated sur- gically, but whether the age at treatment has any effect on the risk is unclear. We stud- ied the relation between the age at treatment for undescended testis and the risk of testicular cancer. METHODS We identified men who underwent orchiopexy for undescended testis in Sweden be- tween 1964 and 1999. Cohort subjects were identified in the Swedish Hospital Discharge Register and followed for the occurrence of testicular cancer through the Swed ish Cancer Registry. Vital statistics and data on migration status were taken from the I Register of Population and Population Changes for the years 1965 through 2000. We estimated the relative risk of testicular cancer using Poisson regression of standard- : ized incidence ratios, comparing the risk in the cohort with that in the general population. We also analyzed the data by means of Cox regression, using internal comparison groups. RESULT The cohort consisted of16,983 men who were surgically treated for undescended testis and followed for a total of209,984 person-years. We identified 56 cases of testicular cancer during follow-up. The relative risk of testicular cancer among those who underwent orchiopexy before reaching 13 years of age was 2.23 (95% confidence interval [CI], 1.58 to 3.06), as compared with the Swedish general population; for those treated at 13 years of age or older, the relative risk was 5.40 (95% CI, 3.20 to 8.53). The effect of age at orchiopexy on the risk of testicular cancer was similar in comparisons within the cohort. CONCLUSIONS Treatment for undescended testis before puberty decreases the risk of testicular cancer.

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