Once-Yearly Zoledronic Acid for Treatment of Postmenopausal Osteoporos  

Oleh:

Black, Dennis M. ; Delmas, Pierre D ; Eastell, Richard ; Boonen, Steven ; Cauley, Jane A. ; Cosman, Felicia ; Leung, Ping Chung ; Man, Zulema ; Mautalen, Carlos ; Mesenbrink, Peter ; Caminis, John ; Tong, Karen ; Rosario-jansen, Theresa ; Krasnow, Joel ; Sellmeyer, Deborah ; Fink Eriksen, Erik ; Cummings, Steven R.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 356 no. 18 (May 2007), page 1809.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2007.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

BACKGROUND A single infusion of intravenous zoledronic acid decreases bone turnover and improves bone density at 12 months in postmenopausal women with osteoporosis. We assessed I the effects of annual infusions of zoledronic acid on fracture risk during a 3-year : period. METHODS In this double-blind, placebo-controlled trial, 3889 patients (mean age, 73 years) were randomly assigned to receive a single IS-minute infusion of zoledronic acid (5 mg) I and 3876 were assigned to receive placebo at baseline, at 12 months, and at 24 months; the patients were followed until 36 months. Primary end points were new vertebral: fracture (in patients not taking concomitant osteoporosis medications) and hip frac- ! ture (in all patients). Secondary end points included bone mineral density, bone turn-over markers, and safety outcomes. RESULTS Treatment with zoledronic acid reduced the risk of morphometric vertebral fracture by 70% during a 3-year period, as compared with placebo (3.3% in the zoledronic-acid group vs. 10.9% in the placebo group; relative risk, 0.30; 95% confidence interval [CI], ( 0.24 to 0.38) and reduced the risk of hip fracture by 41% (1.4% in the zoledronic-acid B group vs. 2.5% in the placebo group; hazard ratio, 0.59; 95% CI, 0.42 to 0.83). Non- ~ vertebral fractures, clinical fractures, and clinical vertebral fractures were reduced by s 25%, 33%, and 77%, respectively (P

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