Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study  

Oleh:

Anderson, Katie B ; Chunsuttiwat, Supamit ; Nisalak, Ananda ; Mammen, Mammen P. ; Libraty, Daniel H. ; Rothman, Alan L. ; Green, Sharone ; Vaughn, David W. ; Ennis, Francis A ; Endy, Timothy P.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Lancet (keterangan: ada di Proquest) vol. 369 no. 9571 (Apr. 2007), page 1452.

Ketersediaan

Perpustakaan FK Nomor Panggil: L01.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand. Methods: We did a prospective study in a cohort of children at primary school in northern Thailand from 1998 to 2002. We assessed the burden of dengue illness as disability-adjusted life years (DALYs) and patient costs per illness. Findings: Dengue accounted for 328 (11%) of the 3056 febrile cases identified in 2114 children during the study period. The mean burden of dengue was 465·3 (SD 358·0; range 76·5–954·0) DALYs per million population per year, accounting for about 15% of DALYs lost to all febrile illnesses (3213·1 [SD 2624·2] DALYs per million per year). Non-hospitalised patients with dengue illnesses represented a substantial proportion of the overall burden of disease, with 44–73% of the total DALYs lost to dengue each year due to such illness. The infecting dengue serotype was an important determinant of DALYs lost: DEN4 was responsible for 1% of total DALYs lost, DEN1 for 9%, DEN2 for 30%, and DEN3 for 29%. Interpretation: Use of prospective data to estimate the burden of disease shows that most DALYs lost to dengue illness were the result of non-hospitalised illnesses of long duration. Thus, inclusion of non-hospitalised cases is critical to accurately assess the total burden of dengue illness.

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