Class of Antiretroviral Drugs and the Risk of Myocardial Infarction  

Oleh:

Group, The DAD Study

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 356 no. 17 (Apr. 2007), page 1723.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2007.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

BACKGROUND We have previously demonstrated an association between combination antiretroviral 1 therapy and the risk of myocardial infarction. It is not clear whether this associa- ( tion differs according to the class of antiretroviral drugs. We conducted a study to ~ investigate the association of cumulative exposure to protease inhibitors and non- nucleoside reverse-transcriptase inhibitors with the risk of myocardial infarction. METHODS We analyzed data collected through February 2005 from our prospective observac v tional study of 23,437 patients infected with the human immunodeficiency virus. The incidence rates of myocardial infarction during the follow-up period were calcu- lated, and the associations between myocardial infarction and exposure to protease L inhibitors or non nucleoside reverse-transcriptase inhibitors were determined. RESULTS [ Three hundred forty-five patients had a myocardial infarction during 94,469 person- years of observation. The incidence of myocardial infarction increased from 1.53 per I' 1000 person-years in those not exposed to protease inhibitors to 6.01 per 1000 p person-years in those exposed to protease inhibitors for more than 6 years. After ~ adjustment for exposure to the other drug class and established cardiovascular risk c factors (excluding lipid levels), the relative rate of myocardial infarction per year of ~ protease-inhibitor exposure was 1.16 (95% confidence interval [CI], 1.10 to 1.23), ~ whereas the relative rate per year of exposure to nonnucleoside reverse-transcriptase a inhibitors was 1.05 (95% CI, 0.98 to 1.13). Adjustment for serum lipid levels further A reduced the effect of exposure to each drug class to 1.10 (95% CI, 1.04 to 1.18) and 1.00 (95% CI, 0.93 to 1.09), respectively. CONCLUSIONS Increased exposure to protease inhibitors is associated with an increased risk of ;, myocardial infarction, which is partly explained by dyslipidemia. We found no evidence of such an association for non nucleoside reverse-transcriptase inhibitors; however, the number of person-years of observation for exposure to this class of 1drug was less than that for exposure to protease inhibitors.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali