Detail Regulation of the Germinal Center Response by MicroRNA-155   Oleh:  Thai, To-Ha ; Calado, Dinis Pedro ; Casola, Stefano ; Ansel, K. Mark ; Xiao, Changchun ; Xue, Yingzi ; Murphy, Andrew ; Frendewey, David ; Valenzuela, David ; Kutok, Jeffery L ; Schmidt-Supprian, Marc ; Rajewsky, Nikolaus ; Yancopoulos, George ; Rao, Anjana ; Rajewsky, Klaus Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5824 (Apr. 2007), page 604. Topik: Immunology Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T celldependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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