Detail A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis   Oleh:  Ferguson, Shawn M. ; Brasnjo, Gabor ; Hayashi, Mitsuko ; Wolfel, Markus ; Collesi, Chiara ; Giovedi, Silvia ; Raimondi, Andrea ; Gong, Liang-Wei ; Ariel, Pablo ; Paradise, Summer ; O'Toole, Eileen ; Flave, Richard ; Cremona, Ottavio ; Miesenbock, Gero ; Ryan, Thomas A. ; Camilli, Pietro De Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5824 (Apr. 2007), page 570. Topik: Neuroscience Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Dynamin 1 is a neuron-specific guanosine triphosphatase thought to be critically required for the fission reaction of synaptic vesicle endocytosis. Unexpectedly, mice lacking dynamin 1 were able to form functional synapses, even though their postnatal viability was limited. However, during spontaneous network activity, branched, tubular plasma membrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout mice. Synaptic vesicle endocytosis was severely impaired during strong exogenous stimulation but resumed efficiently when the stimulus was terminated. Thus, dynamin 1- independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved