Detail Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF   Oleh:  Maeda, Takahiro ; Merghoub, Taha ; Hobbs, Robin M. ; Dong, Lin ; Maeda, Manami ; Zakrzewski, Johannes ; Brink, Marcel R.M. Van Den ; Zelent, Arthur ; Shigematsu, Hirokazu ; Akashi, Koichi ; Teruya-Feldstein, Julie ; Cattoretti, Giorgio ; Pandolf, Pier Paolo Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 316 no. 5826 (May 2007), page 860. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into Band T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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